Cytokine Production in Hymenolepis Nana Infection

نویسندگان

  • Aboulghasem Ajami Department of Immunology, Sari Medical School, Mazandaran University of Medical Sciences, Sari, Iran
  • Alireza Rafiei Department of Immunology, Sari Medical School, Mazandaran University of Medical Sciences, Sari, Iran
چکیده مقاله:

Background: Although many experimental studies provide convincing evidence that type II immunity is protective against helminths, recent data in mice demonstrate that Th1 is also impor-tant in some cestodes like Hymenolepis nana. Objective: To identify the role of Th1 and Th2 lymphocytes in immunity against H. nana, the levels of IL-12, IFNγ, IL-5, and IL-13 were de-termined in serum of humans infected with this cestode. Methods: A total of 31 patients (case) with H. nana infection and 30 clinically healthy individuals (control) was included in this study. Measurements of IL-12, IFNγ, IL-13 and IL-5 in serum samples were performed by solid-phase sandwich enzyme linked immunosorbant assay. Differential leukocyte count was also done. T test, Mann Whitney U test and Wilcoxan W test were used for data analysis. Results: The mean concentrations of IFNγ, IL-12 and IL-5 in the sera of patients with H. nana infection were higher than the control group, but only the differences between the concentrations of IFNγ (p

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Cytokine production in Hymenolepis nana infection.

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cytokine production in hymenolepis nana infection

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عنوان ژورنال

دوره 4  شماره 4

صفحات  236- 240

تاریخ انتشار 2007-12-01

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